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US Senator Edward (Teddy) Kennedy"One of the most shameful things about modern America is that in our unbelievably rich land, the quality of healthcare available to many of our people is unbelievably poor, and the cost is unbelievably high.With the sole exception of South Africa, no other industrial nation in the world leaves its citizens in fear or financial ruin because of illness.If national health insurance is good enough for the wealthy and good enough for Congress, then it is good enough for every American citizen in every city, town and village and on every farm throughout this land. But the truth is, we cannot afford not to have national health insurance for our healthcare. 

Quotes researched by freelance writer/researcher Judi Bailey, Ohio

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Protect yourself and your partners health from getting Sexually Transmitted Diseases by using a condom each time you have intimate relations. Always brush your teeth before being intimate, and always wash your entire body before and after being intimate, with soap and water. Take extra care that your hands are clean.

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End Violence Against Children

Learn About Health Research of Clinical Studes at the Mayo Clinic

Contact Us Clinical studies questions Phone: 800-664-4542 (toll-free)

Cancer-related clinical studies questions Phone: 507-538-7623

International patient clinical studies questions Phone: 507-284-8884 Email: intl.mcr@mayo.edu

Millions of U. S. children not getting recommended preventive health care

9-25-2014 CDC officials claim that, millions of infants, children and adolescents in the United States did not receive key clinical health preventive services, according to a report published by the Centers for Disease Control and Prevention (CDC) in today’s Morbidity and Mortality Weekly Report (MMWR) Supplement.

Clinical preventive health services are various forms of important medical or dental care that support healthy development. They are delivered by doctors, dentists, nurses and allied health providers in clinical settings. These services prevent and detect conditions and diseases in their earlier, more treatable stages, significantly reducing the risk of illness, disability, early death, and expensive medical care.

The CDC report focuses on 11 clinical preventive services: prenatal breastfeeding counseling, newborn hearing screening and follow-up, developmental screening, lead screening, vision screening, hypertension screening, use of dental care and preventive dental services, human papillomavirus vaccination, tobacco use screening and cessation assistance, chlamydia screening and reproductive health services.

The findings offer a baseline assessment of the use of selected services prior to 2012, before or shortly after implementation of the Affordable Care Act. Sample findings include:

In 2007, parents of almost eight in 10 (79 percent) children aged 10-47 months reported that they were not asked by healthcare providers to complete a formal screen for developmental delays in the past year.

In 2009, more than half (56 percent) of children and adolescents did not visit the dentist in the past year and nearly nine of 10 (86 percent) children and adolescents did not receive a dental sealant or a topical fluoride application in the past year.

Nearly half (47 percent) of females aged 13-17 years had not received their recommended first dose of HPV vaccine in 2011.

Approximately one in three (31 percent) outpatient clinic visits made by 11-21 year-olds during 2004–2010 had no documentation of tobacco use status; eight of 10 (80 percent) of those who screened positive for tobacco use did not receive any cessation assistance.

Approximately one in four (24 percent) outpatient clinic visits for preventive care made by 3-17 year olds during 2009-2010 had no documentation of blood pressure measurement.

“We must protect the health of all children and ensure that they receive recommended screenings and services. Together, parents and the public health and healthcare communities can work to ensure that children have health insurance and receive vital preventive services,” said Stuart K. Shapira, M.D., Ph.D., chief medical officer and associate director for science in CDC’s National Center on Birth Defects and Developmental Disabilities. Increased use of clinical preventive services could improve the health of infants, children and teens and promote healthy lifestyles that will enable them to achieve their full potential.”

“The Affordable Care Act requires new health insurance plans to provide certain clinical preventive services at no additional cost – with no copays or deductibles," said Lorraine Yeung, M.D., M.P.H., medical epidemiologist with CDC’s National Center on Birth Defects and Developmental Disabilities. “Parents need to know that many clinical preventive services for their children, such as screening and vaccination, are available for free with many health plans.”

 

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Health-Doctors: Beware of Low Diastolic Blood Pressure When Treating Hypertension

12-18-2016 From Johns Hopkins Health Researchrs,By analyzing medical records gathered over three decades on more than 11,000 Americans participating in a federally funded study, researchers at Johns Hopkins Medicine say they have more evidence that driving diastolic blood pressure too low is associated with damage to heart tissue.

The researchers caution that their findings cannot prove that very low diastolic blood pressure — a measure of pressure in arteries between heartbeats when the heart is resting and also the “lower” number in a blood pressure reading — directly causes heart damage, only that there appears to be a statistically significant increase in heart damage risk among those with the lowest levels of diastolic blood pressure.

“The take-home message is there is increased likelihood that if we use blood pressure drugs to push patients’ systolic blood pressures down to 120, which is a strategy supported by recent clinical trials, the consequence in those starting out with low diastolic blood pressures (e.g., below 80) may be that the diastolic number falls so low that we risk doing damage,” says J. William McEvoy, M.B.B.Ch., M.H.S., assistant professor of medicine and member of the Ciccarone Center for the Prevention of Heart Disease at the Johns Hopkins University School of Medicine. “Our key finding suggests that for some patients, there should perhaps be modification of intensive anti-hypertensive treatment recommendations issued last year as a result of the SPRINT trial, and that physicians shouldn’t look at driving down the top blood pressure number (the systolic number) in isolation without considering implications of lowering the bottom number.”

A summary of the findings was published Aug. 30 in the Journal of the American College of Cardiology and coincides with the release of a similar analysis at the European Society of Cardiology Meeting by physicians from Hôpital Bichat in Paris, France.

Health CDC Restores Emergency Preparedness Funds to States and Territories"

10-24-2016 Florida to receive $2.6 million in funding that can be used to fight Zika. The Centers for Disease Control and Prevention (CDC) has increased by $44.25 million the Public Health Emergency Preparedness (PHEP) cooperative agreements for all-hazards preparedness efforts in 2016 and 2017. The funds will go to a total of 62 jurisdictions, including US states, cities, and territories.

The funds are part of the fiscal year 201‎6‎ Zika supplemental funding passed by Congress on Sept. 28, 2016, and signed by the president on Sept. 29, 2016. This increase restores PHEP funds previously redirected from states and other jurisdictions in March 2016 to support CDC’s Zika response.

"These CDC funds will enable states, cities, and territories to maintain and improve their routine preparedness and response efforts against a myriad of health threats,” said Stephen C. Redd, M.D. (RADM, USPHS), director of CDC’s Office of Public Health Preparedness and Response. “We appreciate being able to make the PHEP-funded awardees‎ whole again to continue their vital work preparing for and responding to natural disasters and disease outbreaks.”

Recipients will start receiving funding the week of October 17, 2016. They can use the funds to prepare for any type of public health emergency, including Zika.

The PHEP cooperative agreement is a critical source of funding for state, local, tribal, and territorial public health departments. Since 2002, the PHEP cooperative agreement has been the sole source of federal funding in support of public health emergency preparedness nationwide. In total, public health departments receive more than $9 billion to upgrade their ability to effectively respond to a range of public health threats, including infectious diseases; natural disasters; and biological, chemical, nuclear, and radiological events. Preparedness activities funded by the PHEP cooperative agreement are intended to help state and local public health departments develop flexible, adaptable response plans.

Salmonela in Backyard Chicken Farms

8-1-2016 Illnesses that started after June 16, 2016 might not be reported yet due to the time it takes between when a person becomes ill and when the illness is reported. This takes an average of 2 to 4 weeks.

Investigation Update

Epidemiologic, traceback, and laboratory findings have linked the eight outbreaks to contact with live poultry such as chicks and ducklings from multiple hatcheries.

In interviews, ill people answered questions about contact with animals and foods consumed during the week before becoming ill. Contact with live poultry (chicks, chickens, ducks, ducklings) in the week before becoming ill was reported by 434 of 493 ill people interviewed, or 88%.

Ill people reported purchasing live baby poultry from several suppliers, including feed supply stores, Internet sites, hatcheries, and friends in multiple states. Ill people reported purchasing live poultry to produce eggs, learn about agriculture, have as a hobby, enjoy for fun, keep as pets, or to give as Easter gifts. Some of the places ill people reported contact with live poultry include their home, someone else’s home, work, or school settings. While having a backyard farm of chickens sounds like a good idea,there are many problems ypu might not have thought about.

Public health officials collected samples from live poultry and the environments where the poultry live and roam from the homes of ill people in several states. Laboratory testing isolated four of the outbreak strains of Salmonella.

Papa Johns Recalls Chicken and Salads

5-21-2016 Papa John’s Salads and Produce, a Tolleson, Ariz. establishment, is recalling approximately 373 pounds of ready-to-eat salad with chicken products that may be adulterated with Listeria monocytogenes, the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) announced today.

The Signature Café Citrus Kale Salad with Chicken items were produced from May 10 through May 17, 2016. The following products are subject to recall: [View Label (PDF Only)]

7.5-oz. plastic packages of “Signature Café Citrus Kale Salad with Chicken – Dress with Lemon, Salt and Pepper” with “Use By” dates of May 17 through May 24, 2016. The packages will have the following UPC code of 2113008148.

The products subject to recall bear establishment number “P-40280” inside the USDA mark of inspection. These items were shipped to retail locations in Colorado, Idaho, Minnesota, Montana, Nebraska, New Mexico, South Dakota and Wyoming.

The problem was discovered on May 19, 2016, when the establishment was notified by SunOpta that its sunflower kernel products used in Papa John’s Salads and Produce products were involved in a recall due to possible contamination with Listeria monocytogenes. There have been no confirmed reports of adverse reactions due to consumption of these products.

SunOpta’s recall can be found at: http://www.fda.gov/Safety/Recalls/ucm502184.htm

Consumption of food contaminated with Listeria monocytogenes can cause listeriosis, a serious infection that primarily affects older adults, persons with weakened immune systems, and pregnant women and their newborns. Less commonly, persons outside these risk groups are affected.

Listeriosis can cause fever, muscle aches, headache, stiff neck, confusion, loss of balance and convulsions sometimes preceded by diarrhea or other gastrointestinal symptoms. An invasive infection spreads beyond the gastrointestinal tract. In pregnant women, the infection can cause miscarriages, stillbirths, premature delivery or life-threatening infection of the newborn. In addition, serious and sometimes fatal infections in older adults and persons with weakened immune systems. Listeriosis is treated with antibiotics. Persons in the higher-risk categories who experience flu-like symptoms within two months after eating contaminated food should seek medical care and tell the health care provider about eating the contaminated food.

Consumers who have purchased these products are urged not to consume them. These products should be thrown away or returned to the place of purchase.

Garland Ventures in Texas Food Recall

5-21-2016 Garland Ventures LTD, a Garland, Texas establishment, is recalling approximately 114,870 pounds of chicken fried rice products that may be adulterated with Listeria monocytogenes, the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) announced today.

The heat-treated, not fully cooked, not shelf stable chicken fried rice products were produced on various dates between Sept. 24, 2015 and Mar. 23, 2016. The following products are subject to recall: More

20 oz. pail boxes containing AllFresh Foods “ANJOY Chicken Fried Rice.” Case Codes associated with the “ANJOY Chicken Fried Rice” product are as follows: 092415, 092915, 100215, 101315, 101615, 102015, 102715, 110315, 110615 and 032316.

The products subject to recall bear establishment number “P-31993” inside the USDA mark of inspection. These items were shipped to retail distributor locations in Colorado, Georgia, Missouri, and Utah.

The problem was discovered when Garland Ventures LTD was notified by their supplier of vegetable fried rice, Ajinomoto Windsor Inc., that frozen foods involved in CRF Frozen Foods’ recall were incorporated in their products. CRF Frozen Foods of Pasco, Washington voluntarily recalled frozen vegetable items due to an illness outbreak of listeriosis. There have been no confirmed reports of illness or adverse reactions due to consumption of Garland Ventures’ products.

The CRF Frozen Foods’ recall can be found at http://www.fda.gov/Safety/Recalls/ucm498841.htm.

Am I at Risk of Type 2 Prediabetes

3-26-2016 What is type 2 diabetes?According to NIH,Type 2 diabetes, formerly called adult-onset diabetes, is the most common type of diabetes. About 95 percent of people with diabetes have type 2. People can develop type 2 diabetes at any age, even during childhood. However, this type of diabetes develops most often in middle-aged and older people. People who are overweight and inactive are also more likely to develop type 2 diabetes.

In type 2 and other types of diabetes, you have too much glucose, also called sugar, in your blood. People with diabetes have problems converting food to energy. After a meal, food is broken down into glucose, which is carried by your blood to cells throughout your body. With the help of the hormone insulin, cells absorb glucose from your blood and use it for energy. Insulin is made in the pancreas, an organ located behind the stomach.

Type 2 diabetes usually begins with insulin resistance, a condition linked to excess weight in which your body’s cells do not use insulin properly. As a result, your body needs more insulin to help glucose enter cells. At first, your pancreas keeps up with the added demand by producing more insulin. But in time, your pancreas loses its ability to produce enough insulin, and blood glucose levels rise.

Over time, high blood glucose damages nerves and blood vessels, leading to problems such as heart disease, stroke, kidney disease, blindness, dental disease, and amputations. Other problems of diabetes may include increased risk of getting other diseases, loss of mobility with aging, depression, and pregnancy problems.

Get tested today ,call your doctors office or go to a health clinic. Change your medical condition and your life today

Johns Hopkins New Study to clear infection of Tuberculosis

3-20-2016 In a study using mice, the Johns Hopkins University School of Medicine infectious disease experts have added to evidence that statin drugs — known primarily for their cholesterol-lowering effects — can significantly reduce the time it takes to clear tuberculosis infection

“If our results hold up in humans, the use of statins as adjuncts to standard drug treatment could confer substantial benefits to public health and the nearly nine million new TB patients diagnosed worldwide each year,” says study author Petros Karakousis, M.D., associate professor of medicine in the Division of Infectious Diseases at the Johns Hopkins University School of Medicine. “Because statins like the one we tested are already approved by the U.S. Food and Drug Administration and have a long history of safety in patients, the new data might substantially accelerate their repurposing for tuberculosis patients.”

First-line treatment for tuberculosis, which consists of a combination of four antibiotics, should in theory cure all drug-susceptible infections if strict compliance can be assured. However, says Karakousis, a curative course of treatment usually requires six to nine months, with a minimum of 18 months for drug-resistant forms of the lung disease. To assure compliance, most patients in developed countries undergo directly observed therapy, in which a trained health care worker provides the prescribed drugs and watches patients swallow every dose — a strategy that mitigates spread of the disease but diverts resources from other needed medical care. In many developing countries, patients stop taking their antibiotics early when their symptoms abate, contributing to continued spread of tuberculosis in the community and the emerging problem of drug resistance.

Because new drugs that might shorten treatment duration are few in number and years from clinical use, Karakousis says his team’s focus has been on repurposing already approved medicines that bolster the first-line regimen.

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Find the MEMA List of Needed emergency supplies here<

http://clinicalservicesri.com/new-england-treatment/

This page is the hub for information on treatment and addiction in major regions within the New England. The purpose is to provide unbiased information to help individuals make informed decisions on their local options. It even includes citations of the latest statistics on drug use and treatment in each region.

HPV

8-3-2015 HPV vaccination is the best way to prevent many types of cancer many adolescents haven’t started the hpv vaccine series

HPV vaccination is the best way to prevent many types of cancer many adolescents haven’t started the hpv vaccine series.

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The number of 13- to 17-year-old boys and girls getting the human papillomavirus (HPV) vaccine increased slightly for the second year in a row, according to data from CDC’s 2014 National Immunization Survey-Teen (NIS-Teen), published in this week’s Morbidity and Mortality Weekly Report (MMWR).

Despite these increases, 4 out of 10 adolescent girls and 6 out of 10 adolescent boys have not started the recommended HPV vaccine series, leaving them vulnerable to cancers caused by HPV infections. Persistent HPV infections can cause cancers of the cervix, vagina, and vulva in women; cancers of the penis in men; and cancers of the anus and oropharynx (back of the throat, base of the tongue, and tonsils) in men and women. CDC recommends the vaccine for girls and boys at age 11 to 12 years.

The latest estimates show that 60 percent of adolescent girls and 42 percent of adolescent boys have received one or more doses of HPV vaccine. This was an increase of 3 percentage points for girls and 8 percentage points for boys from the 2013 NIS-Teen survey estimates.

While there was a 3 percentage point overall increase nationally for first-dose HPV vaccine coverage among adolescent girls, a handful of state and local areas achieved much larger increases in coverage.

“The large increases in these diverse parts of the country show us it is possible to do much better at protecting our nation’s youth from cancers caused by HPV infections,” said Dr. Anne Schuchat, assistant surgeon general and director of CDC’s National Center for Immunization and Respiratory Diseases. “We are missing crucial opportunities to protect the next generation from cancers caused by HPV.”

Some of the promising strategies that have been effective in combination at increasing receipt of HPV vaccine include:

Establishing links between cancer organizations and immunization organizations to emphasize HPV vaccination is cancer prevention;

Health care provider education initiatives, including reminding doctors and nurses to take every opportunity to strongly recommend HPV vaccine, especially when they recommend the two other vaccines recommended at age 11 to 12 years (the quadrivalent meningococcal conjugate and Tdap vaccines) and the annual flu vaccine;

Practice-based quality improvement efforts by state and local health departments, such as assessment of a clinic’s HPV vaccination coverage levels and providing feedback on how to improve coverage;

Public communication campaigns; and, Reminder-recall interventions, such as using immunization information systems to send reminders to parents about vaccinations for which their child is due.

The relatively large increases in HPV vaccination seen in some states mask the lack of progress in other states. Every year, about 27,000 women and men in the United States are diagnosed with a cancer caused by HPV infection. HPV vaccination could prevent the majority of these cancers from ever developing.

“HPV vaccine prevents cancer,” said Dr. Schuchat.

Preteens need four vaccines at ages 11 or 12 years to protect against serious diseases: quadrivalent meningococcal vaccine to protect against meningitis; HPV vaccine to protect against HPV infection and HPV cancers; Tdap vaccine to protect against tetanus, diphtheria, and pertussis, or whooping cough; and an annual flu shot to protect against seasonal flu. A second dose of meningococcal vaccine is needed at age 16. 

Johns Hopkins researchers to bring surgical quality improvement initiative to hospitals nationwide

2-14-2017 According to the Johns Hopkins Armstrong Institute for Patient Safety and Quality, in collaboration with the American College of Surgeons, has been awarded a nearly $4 million contract, with the option of $12 million over three years, for a total of about $16 million from the Agency for Healthcare Research and Quality (AHRQ) to improve the outcomes and experiences of surgery patients across the United States. The project, funded and guided by AHRQ, will enable more than 750 hospitals to implement enhanced recovery after surgery (ERAS) protocols, which have been shown to reduce complications, decrease lengths of stay and boost patient experience.

ERAS strategies are employed throughout a patient’s entire care process — from the time a surgeon decides to operate to after a patient is discharged following a procedure. Protocols include patient and family engagement, avoiding prolonged fasting periods, prescribing and using opioids sparingly, and incorporating multiple methods to control pain. ERAS brings a collaborative care approach, involving close teamwork among surgeons, anesthesia providers and nurses.

While these protocols have existed for years, Johns Hopkins took a novel approach to implementing them in 2013. Elizabeth Wick, M.D., who is now an adjunct associate professor of surgery at the Johns Hopkins University School of Medicine, joined ERAS with AHRQ’s Comprehensive Unit-Based Safety Program (CUSP), a five-step culture change intervention that engages front-line health care staff members in preventing harm. CUSP can help overcome the lack of local buy-in that often dooms improvement efforts.

Through the combination of both initiatives, hospital length of stay for patients having colorectal surgery was reduced by about 1.5 days, costs have dropped by $1,500 and patient complications have gone down, including a 50 percent decrease in surgical-site infections.

“With the success of ERAS at our hospital, we are excited to share this approach with other hospitals,” says Michael Rosen, Ph.D., associate professor with the Armstrong Institute. “This will be an important step in improving patient care throughout their surgery process.”

End Violence Against Children

NEW YORK, 13 July 2016 – Today at the United Nations children joined world leaders to launch a new partnership and fund to make ending violence a public priority and a collective responsibility. End Violence Against Children - The Global Partnership brings together governments, foundations, the UN, civil society, academia, the private sector and young people in driving action toward achieving the new global target to end abuse, exploitation, trafficking and all forms of violence and torture against children.

"The Global Partnership to End Violence against Children is mobilizing the world,” said United Nations Secretary-General Ban Ki-moon. “There could be no more meaningful way to help realize the vision of the 2030 Agenda for Sustainable Development."

The world’s governments set ambitious targets to end violence by 2030 as part of the Sustainable Development Goals. Working through the Global Partnership, governments and organizations can pool their resources and expertise to make accelerated progress toward this critical goal.

“Every day, in every country and every community, children are victimized by violence – and far too often, this violence is accepted as normal, permissible, or a private matter,” said Susan Bissell, Director of the Global Partnership. “Violence against children is not inevitable – if we challenge the status quo that harms the lives and futures of so many children. Every child has the right to grow up free from violence – and we all need to work together to realize that vision.”

The Centers for Disease Control and Prevention (CDC) has reported that in the past year as many as 1 billion children around the world have experienced physical, sexual, or psychological violence. Globally, one in four children suffer physical abuse. Nearly one in five girls is sexually abused at least once in her life. Every five minutes, a child dies as a result of violence.

"Violence against children is a problem shared by every society – so the solution must also be shared,” said UNICEF Executive Director Anthony Lake, who serves as founding co-Chair of the Global Partnership Board. “When we protect children from violence we not only prevent individual tragedies and support children’s development and growth. In doing so, we also support the strength and stability of their societies.”

Never Eat Raw Dough

6-1-2016 MINNEAPOLIS – General Mills is collaborating with health officials to investigate an ongoing, multistate outbreak of E. coli O121 that may be potentially linked to Gold Medal flour, Wondra flour, and Signature Kitchens flour (sold in Safeway, Albertsons, Jewel, Shaws, Vons, United, Randalls, and Acme). Out of an abundance of caution, a voluntary recall is being made. To date, E. coli O121 has not been found in any General Mills flour products or in the flour manufacturing facility and the company has not been contacted directly by any consumer reporting confirmed illnesses related to these products.

State and federal authorities have been researching 38 occurrences of illnesses across 20 states related to a specific type of E. coli (E. coli O121), between December 21, 2015, and May 3, 2016. While attempting to track the cause of the illness, CDC found that approximately half of the individuals reported making something homemade with flour at some point prior to becoming ill. Some reported using a General Mills brand of flour.

Based on the information that has been shared with General Mills, some of the ill consumers may have also consumed raw dough or batter. Consumers are reminded to not consume any raw products made with flour. Flour is an ingredient that comes from milling wheat, something grown outdoors that carries with it risks of bacteria which are rendered harmless by baking, frying or boiling. Consumers are reminded to wash their hands, work surfaces, and utensils thoroughly after contact with raw dough products or flour, and to never eat raw dough or batter.

“As a leading provider of flour for 150 years, we felt it was important to not only recall the product and replace it for consumers if there was any doubt, but also to take this opportunity to remind our consumers how to safely handle flour,” said Liz Nordlie, President of General Mills Baking division.

Although most strains of E. coli are harmless, others can make you sick.E. coli O121 is a potentially deadly bacterium that can cause bloody diarrhea and dehydration. Seniors, the very young, and persons with compromised immune systems are the most susceptible to foodborne illness.

Any consumers concerned about an illness should contact a physician. Anyone diagnosed by a physician as having an illness related to E. coli O121 is also urged to contact state and local public health authorities.

The recall affects the following retail flour products that could be currently in stores or in consumers’ pantries. It includes 6 SKUs (stock keeping units or UPC codes) of Gold Medal Flour, 2 SKU’s of Signature Kitchens Flour and 1 SKU of Gold Medal Wondra flour.

If you have any of the products listed below, they should be thrown away. Consumers with additional questions or requesting a replacement should contact the company at 800-230-8103. Additional recall information can also be found at www.generalmills.com/flour.

Are You At Risk for Zika?

At A Glance - Zika in the U.S. (as of June 1,, 2016)US States

Only two people in the US have been diagnosed with Zika virus. Travel-associated Zika virus disease cases reported: 503 Locally acquired vector-borne cases reported: 0

Total: 503

Pregnant: 48

Sexually transmitted: 10

Guillain-Barré syndrome: 1

US Territories

Travel-associated cases reported: 3

Locally acquired cases reported: 698

Total: 701

Pregnant: 65

Guillain-Barré syndrome: 5

Here is What You Can Do at Home to Keep Mosqutos Away from your home

Build your own Zika Prevention Kit.

Metformin

A new analysis of 204 studies involving more than 1.4 million people suggests that metformin, the most frequently prescribed stand-alone drug for type 2 diabetes, reduces the relative risk of a patient dying from heart disease by about 30 to 40 percent compared to its closest competitor drug, sulfonylurea.

The study, designed to assess the comparative — not absolute or individual — benefits and risks of more than a dozen FDA-approved drugs for lowering blood sugar in type 2 diabetes, is described in the April 19 issue of the Annals of Internal Medicine. Diabetes now affects almost 10 percent of the U.S. population and poses a growing public health threat, and most people will eventually need drug treatment, the researchers say.

“Metformin looks like a clear winner,” says Nisa Maruthur, M.D., M.H.S., assistant professor of medicine at the Johns Hopkins University School of Medicine. “This is likely the biggest bit of evidence to guide treatment of type 2 diabetes for the next two to three years.” 

Maruthur, the lead author on the meta-analysis, notes that cardiovascular fatalities — heart attacks and strokes — are major risks for people with uncontrolled blood sugar, but it has never been clear if one diabetes drug is better than another at lowering these fatalities. Other diabetes-related complications include blindness, kidney failure and limb amputations.

This review, Maruthur says, provides a much-needed update to two previous analyses, the last one published in 2011. Since then, researchers have published more than 100 new studies comparing the effectiveness of various blood sugar-lowering drugs, and several new drugs have also come on the market since the last report.

Of the total 204 studies analyzed, 50 spanned several continents, while others were conducted across Europe, Asia and the United States. Most of the studies were short term, with only 22 mostly observational studies lasting more than two years. Participants in the studies were generally overweight with uncontrolled blood sugar levels. Many studies excluded the elderly and those with significant health problems. Just shy of half of the studies made no mention of race or ethnicity. When researchers did report that information, only 10 to 30 percent of participants were nonwhite. 

Maruthur says the new analysis not only looked at cardiovascular disease but also other drug effects, including glucose control, and common side effects, such as weight gain, hypoglycemia and gastrointestinal problems. Because the majority of patients with type 2 diabetes end up using multiple blood sugar-lowering drugs, Maruthur and her team also evaluated how the drugs performed when used alone or in combination. While some of the various studies’ participants were on insulin, this injectable drug was only evaluated when used in combination with other drugs.

 

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Higher Vitamin D Levels Associated With Markedly Improved Survival in Patients With Advanced Colorectal Cancer

2-6-2015 ASCO Perspective: “In addition to improved survival, high vitamin D levels were associated with a longer time for the cancer to become resistant to chemotherapy, suggesting that vitamin D could slow down the growth of the cancer or enhance the activity of the health treatment,” said Smitha S. Krishnamurthi, MD, moderator of today’s presscast and ASCO expert.

“Further studies are needed to determine if the improved health survival is due to the vitamin D itself or to some other factor associated with having high vitamin D levels.”

ALEXANDRIA, Va. – A prospective analysis of data from a phase III study of patients newly diagnosed with metastatic colorectal cancer indicates that patients with higher vitamin D levels have better outcomes after treatment with chemotherapy and targeted therapy. The median overall survival for patients with the highest vitamin D levels was 32.6 months, compared with 24.5 months for patients with the lowest levels. The study will be presented at the upcoming 2015 Gastrointestinal Cancers Symposium in San Francisco.

This study adds to growing evidence of the anti-tumor effects of vitamin D that have been observed in preclinical and epidemiologic research. Randomized studies are underway to confirm the value of taking vitamin D supplements before and after cancer diagnosis.

“Our study adds to the body of research showing that higher vitamin D levels are associated with significantly improved survival. The ultimate goal is to translate this research into an effective intervention for patients by conducting randomized trials of vitamin D supplementation for treatment of colorectal cancer,” said lead study author Kimmie Ng, MD, MPH, assistant professor of medicine at Dana-Farber Cancer Institute, Harvard Medical School in Boston, MA. “It is too early to recommend vitamin D as a treatment for colon cancer, but we do know that maintaining adequate vitamin D levels has other health benefits, such as for bone health.”

Researchers measured blood levels of vitamin D (25-hydroxyvitamin D) in 1,043 patients at the time they were enrolled in CALGB 80405, a phase III trial comparing three different first-line treatments for newly diagnosed, advanced colorectal cancer (chemotherapy plus bevacizumab, cetuximab, or bevacizumab and cetuximab). Patient vitamin D levels ranged from an average of 8 ng/mL in the lowest group to an average of 27.5 ng/mL in the highest group, with the average in all patients being 17.2 ng/mL (the recommended healthy range is 20-30 ng/mL). Older age, black race, lower dietary and supplemental vitamin D intake, higher body-mass index (BMI), worse general physical condition, and lower physical activity were all associated with lower vitamin D levels. Patients whose blood specimens were drawn in the winter and spring months also had significantly lower vitamin D levels, as did patients who resided in the Northern and Northeastern parts of the United States. All these factors have previously been found to be linked to lower vitamin D levels. Overall, very few of the patients reported vitamin D supplement use.

For the purpose of analysis, patients were divided into five groups based on vitamin D levels. After adjusting for prognostic factors and healthy behavior, researchers found that patients in the group with the highest levels of vitamin D lived significantly longer (32.6 months on average), compared with those in the group with the lowest levels (24.5 months on average). Higher vitamin D levels were also associated with longer time to disease progression (12.2 months in the group with the highest levels vs. 10.1 months in the group with the lowest). No significant differences were seen with regard to the type of therapy the patients received.

Dr. Ng indicated that ongoing clinical trials are exploring the potential impact of vitamin D supplementation on cancer prevention and treatment.

 

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Large Wedding Photography by Diane Knaus

wedding photography by diane knaus

By Diane Knaus

Bookmark www.911info.net

Be thankful everyday for something or someone in your life

darlin photo by diane knaus photographer copyrighted

Photo by Diane Knaus ©2010-2014

Do you want a new pet

12-14-2014 There are thousands of pets available at your local SPCA organizations in your cities. Save the pets we already have, they need your love now. There are national organizations available to help you adopt a rescue animal who may have been abused. See PGAA's Rescue Contacts - National and State Listings

E-mail the Webmaster Copyright ©2009-2011 All Rights Reserved / No part of this web site may be used without prior written permission.

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911 Please help support our site and donate to www.911info.net today

Online now for 12 years, we need your help to support our site. Please donate today.

We rely on donations to operate our organization. If everyone reading this donated $12.00, only a dolllar for each year online,we would only have to fundraise 1 day a year.You can choose how much you want to donate. This is a secure site. Thank you for your generous donation. SSL Safe and Secure Certification # 12253525149618858 (2B:88:84:25:CA:12:AA)

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Announcing 911 personal/professional assistance growth services

What 911 type of services do you need to help make your life run smoother? Do you need coaching for spiritual enhancement, personal or professional growth? Do you need to have wake up calls for important meetings? Do you need birthdays, anniversary, or special event reminders? Corporate event messages sent on a regular basis, 911 will perform these services for you. "Develping Premium Packages Only."Email us today confidentiality guaranteed.

 

Do not ever leave children, pets, or older people in hot or cold cars while you shop or run errands

photograph of entertainer in Canada

Large Wedding Photography by Diane Knaus

wedding photography by diane knaus

By Diane Knaus

Bookmark www.911info.net

Be thankful everyday for something or someone in your life

darlin photo by diane knaus photographer copyrighted

Photo by Diane Knaus ©2010-2014

Do you want a new pet

12-14-2014 There are thousands of pets available at your local SPCA organizations in your cities. Save the pets we already have, they need your love now. There are national organizations available to help you adopt a rescue animal who may have been abused. See PGAA's Rescue Contacts -National and State Listings

911 Please help support our site and donate to www.911info.net today

Online now for 12 years, we need your help to support our site. Please donate today.

We rely on donations to operate our organization. If everyone reading this donated $12.00, only a dolllar for each year online,we would only have to fundraise 1 day a year.You can choose how much you want to donate. This is a secure site. Thank you for your generous donation. SSL Safe and Secure Certification # 12253525149618858 (2B:88:84:25:CA:12:AA)

ssl image

Announcing 911 personal/professional assistance growth services

What 911 type of services do you need to help make your life run smoother? Do you need coaching for spiritual enhancement, personal or professional growth? Do you need to have wake up calls for important meetings? Do you need birthdays, anniversary, or special event reminders? Corporate event messages sent on a regular basis, 911 will perform these services for you. "Develping Premium Packages Only."Email us today confidentiality guaranteed.

 

Do not ever leave children, pets, or older people in hot or cold cars while you shop or run errands

photograph of entertainer in Canada

Large Wedding Photography by Diane Knaus

wedding photography by diane knaus

By Diane Knaus

Bookmark www.911info.net

Be thankful everyday for something or someone in your life

darlin photo by diane knaus photographer copyrighted

Photo by Diane Knaus ©2010-2014

Do you want a new pet

12-14-2014 There are thousands of pets available at your local SPCA organizations in your cities. Save the pets we already have, they need your love now. There are national organizations available to help you adopt a rescue animal who may have been abused. See PGAA's Rescue Contacts -National and State Listings

E-mail the WebmasterCopyright ©2009-2011 All Rights Reserved / No part of this web site may be used without prior written permission.

Web Design with Macromedia DreamWeaver CS4